Where is doxorubicin used?Asked by: Joey Quitzon Sr.
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Doxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (cancer that begins in the cells of the immune system); and certain types of leukemia (cancer of the white blood cells ...View full answer
Hereof, What cancers are treated with doxorubicin?
- Acute lymphoblastic leukemia (ALL).
- Acute myeloid leukemia (AML).
- Breast cancer. ...
- Gastric (stomach) cancer that is metastatic.
- Hodgkin lymphoma.
- Neuroblastoma that is metastatic.
- Non-Hodgkin lymphoma.
In this regard, What is the target of doxorubicin?. Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
Herein, What kind of chemo is doxorubicin?
Doxorubicin is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Doxorubicin is classified as an “anthracycline antibiotic.” (For more detail, see “How Doxorubicin Works” section below).
What is Red Devil chemo used for?
For decades, the chemotherapy drug doxorubicin has been part of the arsenal in treating patients with several forms of cancer, including breast cancer and leukemia. The potent drug is a part of a class of compounds known as anthracyclines and is used to treat an estimated one million cancer patients each year.
Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it's used to treat a wide variety of cancers. Unfortunately, the drug can also damage heart cells, so a patient can't take it indefinitely.
During the 3 decades, the proportion of survivors treated with chemotherapy alone increased (from 18% in 1970-1979 to 54% in 1990-1999), and the life expectancy gap in this chemotherapy-alone group decreased from 11.0 years (95% UI, 9.0-13.1 years) to 6.0 years (95% UI, 4.5-7.6 years).
Get medical help right away if you have any very serious side effects, including: chest pain. Within days to weeks after doxorubicin treatment, a serious skin reaction that looks likes a severe sunburn (radiation recall) may develop on any area of skin that has been previously treated with radiation.
Call your doctor right away if you have cough, fast or slow heartbeat, abnormal heartbeat, swelling in the arms or legs, shortness of breath, sudden weight gain, or feel very tired or weak. You will need to have heart function tests while taking this drug.
It is to be expected and only lasts for 1 or 2 days after each dose is given. Do not take other medicines unless they have been discussed with your doctor.
One notable example is heart damage following treatment with Adriamycin (doxorubicin). With this drug, a possible long-term side effect is weakening of the heart muscle, resulting in a decreased ability to pump blood through the body (heart failure).
Doxorubicin May Cause Heart Damage
While other anthracyclines (like epirubicin and mitoxantrone) may also cause heart damage, the chances are more common with doxorubicin. Doxorubicin causes both early and late heart damage (also called cardiotoxicity).
Doxorubicin is an anthracycline type of chemotherapy that is used to treat several different types of cancer. Learn more about this drug here. This is a generic drug. The average cost for 1 Vial, 25ml of 2mg/ml each of the generic (doxorubicin hcl) is $75.99.
Doxorubicin comes as a solution (liquid) or as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given once every 21 to 28 days.
After two cycles of AC, the median tumor shrinkage was 18.3%, whereas treatment with docetaxel provided an additional median tumor shrinkage of 34.2%. Pathological complete remission was observed in 5 patients (11.9%), whereas 26 patients (61.9%) experienced a partial response.
In the world of cancer treatment, Adriamycin is often called the “Red Devil,” both for its bright, red Kool-Aid color and its nasty side effects. The drug can cause tissue damage if not administered correctly. It can also cause heart damage, though that's a lesser occurring side effect.
If this medication accidentally leaks into surrounding tissue, the skin/muscle may be severely damaged. Notify your doctor immediately if redness, blistering, sores, pain, or swelling occur at or near the injection site. Doxorubicin may cause heart problems, including possibly fatal heart failure.
v Hair loss is unusual with liposomal doxorubicin, but some patients do experience more hair loss than others. If hair loss occurs, hair growth should return upon completion of treatment.
Doxorubicin leads to a severe loss of body weight and anorexia with a disruption in systemic metabolism CT DOX.
This agent has earned its infamous nickname, the red devil, based on its bright red (Kool-Aid red) color, vesicant properties, and side-effect profile, including hair loss, myelosuppression, nausea and vomiting, mouth sores, and rare but serious cardiotoxicity.
Thrombotic risk associated with chemotherapy including doxorubicin (DOX) has been frequently reported; yet, the exact mechanism is not fully understood. Here, we report that DOX can induce procoagulant activity in platelets, an important contributor to thrombus formation.
60 mg/m(2) IV every 14 days.
The study authors said a wide-ranging review of scientific evidence found that: Chemotherapy, radiation therapy and other cancer treatments cause aging at a genetic and cellular level, prompting DNA to start unraveling and cells to die off sooner than normal.
“We'll have time after chemo to get back to a better diet,” Szafranski says.
- Fortify with supplements. ...
- Control nausea. ...
- Fortify your blood. ...
- Manage stress. ...
- Improve your sleep.
Skin changes also occur during chemotherapy. Certain chemotherapy drugs can cause temporary redness in the face and neck. This happens when the blood capillaries, which are the smallest part of blood vessels, enlarge and expand. The skin also can get dry, become darker or even more pale.